Lychee (Litchi chinensis Sonn.), belonging to the Sapindaceae family and the Litchi genus, is native to southern China and is highly favored for its delicious taste. In recent years, many research teams have found that lychee has anti-inflammatory, hypoglycemic, anti-tumor, and anti liver fibrosis effects. The active ingredient is mainly flavonoids, so lychee flavonoids have great potential medicinal value. Flavonoids are widely present in nature, such as fruits, tea, vegetables, medicinal plants, etc. It plays an important role in plant growth, development, flowering, fruiting, and other aspects. At the same time, flavonoids also have pharmacological activities such as antibacterial and antiviral activity, anti-tumor activity, antioxidant free radical activity, anti-inflammatory, and hepatoprotective activity. With the continuous deepening of research on lychee, it has been found that in addition to the presence of flavonoids in lychee flesh, lychee skin and core also contain a large number of different types of flavonoids.