Shiitake Mushroom (Lentinus edodes) are the second largest mushroom in the world in terms of production. Mushrooms are known as "mountain treasures" in folk culture and are a dual-use fungus for medicine and food. Shiitake Mushrooms are mainly cultivated in East Asia, especially in China. Shiitake Mushrooms are rich in fat, protein, crude fiber, carbohydrates, vitamins, and trace elements, and are known as the "queen of mushrooms". Shiitake Mushroom has a variety of medicinal values. The oleic acid and linoleic acid in Shiitake Mushroom can prevent and treat atherosclerosis. In addition, active substances such as polysaccharide, interferon and interferon inducer have the functions of enhancing immunity, anti-tumor, antithrombotic, reducing blood fat, preventing rickets, strengthening stomach and protecting liver, assisting fat oxidation, and treating anemia. Shiitake Mushrooms have high medicinal value and no obvious toxic side effects, and have broad prospects for application in the fields of medicine and healthcare.